N-Acetyl Epithalon Amidate (Nasal Spray) – Product Details

N-Acetyl Epithalon Amidate is a modified form of Epithalon. It is a synthetic tetrapeptide that is studied in relation to compounds derived from the pineal gland. This version includes both N-acetylation and C-terminal amidation, structural changes that enhance peptide stability and resistance to enzymatic breakdown. Due to these modifications, the compound is often utilized in research settings for studying peptide structure, stability, and interactions within biological systems.

In experimental studies, N-Acetyl Epithalon Amidate has been investigated for its role in cellular and molecular processes. Research has particularly focused on its effects on telomere regulation, oxidative stress pathways, and cellular signaling. Research also shows its involvement in epigenetic mechanisms and its influence on cellular differentiation models.

Working Mechanism of N-Acetyl Epithalon Amidate

N‑Acetyl Epithalon Amidate, like its parent peptide Epithalon, is studied primarily for its influence on cellular aging pathways in experimental systems. Research indicates it may interact with mechanisms that regulate telomerase expression. This interaction potentially supports maintenance of telomere length through upregulation of the catalytic telomerase subunit in treated cell cultures, a process associated with chromosomal stability. 

It has also been investigated for effects on oxidative stress pathways and gene expression modulation in vitro. In research studies, changes in antioxidant enzyme activity and cell signaling have been observed.

Chemical Properties of N-Acetyl Epithalon Amidate 

• CAS Number: 307297-39-8
• Molar Mass: 390.35 g·mol⁻¹
• Chemical Formula: C14H22N4O9
• IUPAC Name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Note: For more research compounds, be sure to explore our selection of Nasal Sprays, including other unique products like MOTS-C Nasal Spray and N-Acetyl Semax Amidate Nasal Spray for further research advancements.

Research Findings on N-Acetyl Epithalon Amidate

In controlled laboratory studies, the tetrapeptide related to Epithalon has been shown to influence telomere dynamics in cell cultures. Treatment of mammalian cell lines increased telomerase activity and extended telomere length. Analyses using qPCR and telomerase assays showed dose‑dependent rises in telomere length and enzyme expression. These results suggest a role in telomere maintenance under experimental conditions.

Research has also studied its effects on antioxidant and cellular stress pathways. In aging cell models, peptide exposure reduced intracellular reactive oxygen species. It also affected mitochondrial function, including changes in membrane potential. Indicators of oxidative damage decreased, showing impacts on cellular stress and redox regulation in vitro.

Note: This compound is not approved by the FDA for medical use. It is intended for research purposes only.

Why Buy Reduced N-Acetyl Epithalon Amidate From Behemoth Labz?

Behemoth Labz has established itself as a reliable and reputable source for research compounds since 2014. We take pride in offering the highest-quality products that are backed by independent, third-party-issued Certificates of Analysis for identification, purity, and concentration.

Our commitment to quality extends to every aspect of our business, from same-day processing to free shipping on all orders over $100 and our satisfaction guarantee.

At Behemoth Labz, we understand the importance of having access to the best compounds for research purposes. Our team is dedicated to providing exceptional customer service and ensuring that our customers have access to the compounds they need to conduct groundbreaking research.

We also offer international shipping to our customers around the world. Our team is committed to ensuring that your order arrives after research is needed to fully understand its mechanisms of action and potential applications in the treatment of various conditions.

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Reference Links

Al-dulaimi, S., Thomas, R., Matta, S., & Roberts, T. (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology, 26(5). https://doi.org/10.1007/s10522-025-10315-x

Yue, X., Liu, S.-L., Guo, J.-N., Meng, T.-G., Zhang, X.-R., Li, H.-X., Song, C.-Y., Wang, Z.-B., Schatten, H., Sun, Q.-Y., & Guo, X.-P. (2022). Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging, 14(7), 3191–3202. https://doi.org/10.18632/aging.204007