Product Details: Melanotan 1 Nasal Spray

Melanotan 1 Peptide Nasal Spray contains the synthetic peptide Melanotan 1 (Afamelanotide; NDP‑MSH) in a research-grade liquid. It is a modified version of the natural peptide α-melanocyte-stimulating hormone (α-MSH), designed to be more stable in laboratory studies.

In experimental models, this nasal spray allows Melanotan 1 to reach cells through the nasal lining. It is intended only for research use in controlled laboratory experiments and not for human consumption.

Mechanism of Action

In preclinical models and in vitro studies, Melanotan 1 acts as an agonist of the melanocortin-1 receptor (MC1R). [1]

When it binds to MC1R, it activates adenylyl cyclase, increasing cAMP levels inside cells. This triggers protein kinase A (PKA) and other downstream molecules, including microphthalmia-associated transcription factor (MITF). MITF then regulates enzymes like tyrosinase, which control pigment production. [2]

Properties of Melanotan 1 Nasal Spray: 

• Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉ (synthetic peptide)

• Molecular Weight: ~1646.85 Da

• CAS Number: 75921‑69‑6

• PubChem CID: 16132268

• Synonyms: Melanotan 1, Afamelanotide, MT‑1, 4-Norleucyl-7-phenylalanine-alpha-msh, DTXSID40226843

Research Applications/Benefits of Melanotan 1 Nasal Spray

Receptor Signaling Studies: Helps examine how MC1R activates intracellular signaling. [3]

Melanogenesis Research: Used to study enzyme activity and melanin production in cells. [4]

Signal Transduction Mapping: Supports analysis of cAMP-mediated pathways and transcription regulation. [5]

Peptide Analog Models: Allows researchers to explore how synthetic peptides affect receptor activity and stability. [6]

Why Choose BehemothLabz Melanotan 1 Nasal Spray?

Choose Behemoth Labz, choose quality! We are among the few online sellers that believe in the integrity and purity of products. Our Melanotan 1 Nasal Spray is designed to meet the industrial criteria and the needs of researchers.

Before launching our products, we test them through an independent laboratory to check their purity and ingredients. This procedure maximizes the accuracy and findings of your research experiments.

Additionally, we deliver nationwide and internationally. We use a secure payment system that safeguards your personal information and prevents unauthorized third-party access.

So, purchase MT1 Nasal Spray now and experience quality and purity for your research.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References:

1. Jackson, E., Heidl, M., Imfeld, D., Meeus, L., Schuetz, R., & Campiche, R. (2019). Discovery of a Highly Selective MC1R Agonist Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties. International Journal of Molecular Sciences, 20(24), 6143. 
2. Yasumoto, K., Yokoyama, K., Shibata, K., Tomita, Y., & Shibahara, S. (1994). Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Molecular and Cellular Biology, 14(12), 8058–8070. 
3. Baldini, G., & Phelan, K. D. (2019). The melanocortin pathway and control of appetite—progress and therapeutic implications. Journal of Endocrinology, 241(1), R1–R33. 
4. Bonchev, A. (2026). Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report. Life, 16(2), 265. 
5. Blevins, J. E., Moralejo, D. H., Wolden-Hanson, T. H., Thatcher, B. S., Ho, J. M., Kaiyala, K. J., & Matsumoto, K. (2012). Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 303(12), R1231–R1240. 
6. Quinn, T., Zhang, X., & Miao, Y. (2010, April 1). Targeted Melanoma Imaging and Therapy with Radiolabeled Alpha-Melanocyte Stimulating Hormone Peptide Analogues.