Product Details: Leptin (22-56)

Leptin (22–56) is a synthetic peptide fragment corresponding to amino acid residues 22 through 56 of the full-length leptin protein. Leptin is a cytokine-like signaling molecule involved in the regulation of energy balance, metabolic signaling, and neuroendocrine communication through its interaction with the leptin receptor (Ob-R), a member of the class I cytokine receptor family. [1]

Mechanism of Action

Leptin is involved in the regulation of metabolic signaling and energy-related processes through its action on hypothalamic pathways. It functions as a signaling molecule between adipose tissue and the central nervous system, helping coordinate physiological energy balance mechanisms. [1]

Leptin also contributes to reproductive axis signaling, acting as a permissive factor for activation of the hypothalamic–pituitary–gonadal (HPG) axis. It influences gonadotropin-releasing hormone (GnRH) secretion and supports normal endocrine signaling associated with reproductive function. [2]

In addition, leptin has been shown to influence skeletal development pathways and growth-related signaling centers, linking metabolic status with structural and developmental processes. These effects highlight the interaction between endocrine signaling and skeletal system regulation. [4]

Within the central nervous system, leptin is involved in neuronal signaling and memory-associated pathways, particularly through its activity in the hippocampus. It has been shown to modulate synaptic plasticity and neuronal communication, which are essential processes in cognitive research models. [2]

In transgenic mouse models of neurodegenerative research, leptin has been observed to influence memory-related performance and reduce pathological markers, including amyloid-related accumulation. These effects are associated with modulation of intracellular signaling pathways such as JAK2/STAT3 and improvements in neuronal signaling activity. [3]

Properties of Leptin (22-56):

• Molecular Formula: C₁₇₁H₂₉₈N₅₀O₅₆
• Molecular Weight: 3950 g/mol
• CAS Number: N/A
• PubChem CID: 171397196
• Synonyms: orb321099, G12659

Research Applications/Benefits of Leptin (22-56)

• Leptin Receptor Interaction Studies

Leptin signaling involves receptor binding and activation of intracellular pathways that regulate metabolic and endocrine processes. Fragment-based models are used to investigate how specific regions contribute to receptor interaction. [1]

• Structure–Function Relationship Analysis

Leptin is a multi-domain protein with complex signaling behavior. Peptide fragments such as leptin (22–56) are used in research to examine the role of specific amino acid sequences in receptor binding and signaling. [1][2]

• Reproductive and Endocrine Signaling Models

Leptin plays a role in regulating endocrine signaling pathways, making it relevant in studies of hypothalamic–pituitary–gonadal axis function and hormonal communication. [2]

• Neuronal Signaling and Cognitive Research Models

Leptin has been studied for its effects on neuronal signaling and memory-associated pathways, particularly in experimental systems used to evaluate cognitive function and neurobiological processes. [3]

Why Choose BehemothLabz for Leptin (22-56)?

Choose BehemothLabz, choose quality! We are among the few online sellers that believe in the integrity and purity of products. Our Leptin (22-56) is designed to meet the industrial criteria and the needs of researchers. Before launching our products, we test them through an independent laboratory to check their purity and ingredients. This procedure maximizes the accuracy and findings of your research experiments.  

Additionally, we deliver nationwide and internationally. We use a secure payment system that safeguards your personal information and prevents unauthorized third-party access.

So, purchase Leptin (22-56) now and experience quality and purity for your research.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References

1. Houseknecht, K. L., Baile, C. A., Matteri, R. L., & Spurlock, M. E. (1998). The biology of leptin: A review. Journal of Animal Science, 76(5), 1405–1420.
2. Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002). Leptin and reproduction: A review. Fertility and Sterility, 77(3), 433–444.
3. Greco, S. J., Sarkar, S., Johnston, J. M., Zhu, X., Su, B., Casadesus, G., Ashford, J. W., & Tezapsidis, N. (2010). Leptin reduces Alzheimer’s disease-related pathology and improves memory in a transgenic mouse model. Journal of Alzheimer’s Disease, 19(4), 1155–1167.
4. Maor, G., Rochwerger, M., Segev, Y., & Phillip, M. (2002). Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. Journal of Bone and Mineral Research, 17(6), 1034–1043.