Product Details: Ghrelin Acetate Peptide

Ghrelin is a peptide hormone composed of 28 amino acids, characterized by a unique acyl modification at the serine residue in position 3. This modification involves the attachment of an n-octanoyl group, which is essential for receptor binding and activity in experimental systems [1].

Synthetic ghrelin peptides are produced using solid-phase peptide synthesis to ensure a defined structure and high purity. These peptides are typically supplied in lyophilized form, supporting stability and reproducibility in controlled laboratory environments. Their solubility in aqueous buffers makes them suitable for biochemical assays, receptor-binding studies, and molecular signaling investigations in vitro [2].

Mechanism of Action

GHS-R1a Receptor Interaction

Ghrelin interacts with the growth hormone secretagogue receptor type 1a (GHS-R1a), a G protein-coupled receptor expressed in various experimental cell systems. Binding of acylated ghrelin initiates intracellular signaling cascades mediated by G proteins [1][2].

Intracellular Signaling Pathways

Activation of GHS-R1a in experimental models has been associated with downstream signaling pathways involving calcium mobilization and transcriptional regulation. These pathways are commonly studied in vitro to analyze receptor activation and ligand specificity [2][3].

Role of Acyl Modification

The n-octanoyl modification is required for receptor binding and functional activity in biochemical assays. This structural feature supports consistent receptor interaction and enables controlled investigation of ligand–receptor dynamics in experimental systems [1].

Research Applications/Benefits Ghrelin Acetate Peptide

• Receptor Binding Studies: Enables investigation of GHS-R1a ligand interaction and receptor activation in vitro [2]
• Signal Transduction Research: Supports analysis of intracellular pathways associated with GPCR activation [2][3]
• Peptide Stability and Kinetics: Used in experimental models to study peptide degradation and receptor interaction dynamics [3]
• Molecular Signaling Analysis: Provides a controlled system for examining ligand-specific signaling mechanisms [1]

Why Choose BehemothLabz for Ghrelin Acetate Peptide?

Choose BehemothLabz, choose quality! We are among the few online sellers that believe in the integrity and purity of products. Our Ghrelin Acetate Peptide is designed to meet the industrial criteria and the needs of researchers. Before launching our products, we test them through an independent laboratory to check their purity and ingredients. This procedure maximizes the accuracy and findings of your research experiments.  

Additionally, we deliver nationwide and internationally. We use a secure payment system that safeguards your personal information and prevents unauthorized third-party access.

So, purchase Ghrelin Acetate Peptide now and experience quality and purity for your research.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References: 

1. Kojima, M., et al. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656–660.
2. Camina, J. P., et al. (2004). Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a. Endocrinology, 145(2), 930–940.
3. Liu, Y., et al. (2015). Novel bioluminescent receptor-binding assays for peptide hormones: using ghrelin as a model. Amino Acids, 47(10), 2237–2243.